Paolo Bianco received his MD cum laude at the University of Rome La Sapienza (Italy) in 1979, and in 1982 he got Board Certified Anatomic Pathology cum laude at the same university. From 1982 to 1983 he was a Visiting Fellow at the Dept of Anatomy & Dev. Biology at London University College. From 1983 to 1992 he worked as Assistant Professor of Pathology at the University La Sapienza, and was Visiting Associate at the Bone Research Branch, NIDR at NIH (Bethesda MD) between 1988 and 1989. From 1992 to 2000 Paolo Bianco worked as Associate Professor of Pathology at the University of l' Aquila. From 1999 to 2007 he was Adjunct Senior Investigator in the Craniofacial and Skeletal Diseases Branch at NIDCR, NIH. Paolo Bianco has been Professor of Pathology (Anatomic Pathology) at the Medical School & Department of Experimental Medicine & Pathology at La Sapienza University since 2000, since 2004 he has been Director of Anatomic Pathology at Policlinico Umberto I University Hospital of La Sapienza University, and he has been directing the Stem Cell unit at IBCIT at SPR since 2002.

Paolo Bianco's main scientific interests focus on genetic, metabolic and neoplastic diseases of the skeleton; skeletal stem cells, mesodermal stem cells, including biology, disease and cell therapy.

 

Web site: http://www.bianco-lab.it

Selected publications

 

Bianco P, Gehron Robey P, Simmons P: Mesenchymal stem cells: revisiting history, concepts and assays. CellStemCell 2:313-319, 2008

 

Dellavalle, A, Sampaolesi, M, Tonlorenzi, R,  Tagliafico, E,  Sacchetti, B,  Perani, L,, Innocenzi, B,  Galvez, BG,  Messina, G,   Morosetti, R,  Li, S,  Belicchi, M,  Peretti, G,  Chamberlain, JS,  Wright, WE,  Torrente, Y,   Ferrari, S,   Bianco, P and Cossu, G. Pericytes of human post-natal skeletal muscle are myogenic precursors, distinct from satellite cells, and efficiently repair dystrophic muscle. Nature Cell Biology 9: 255-267, 2007

Mosig RA, Bowling O, DiFeo A, Ramirez MCM, Parker IC, Abe E, Diouri J, Al Aqeel A, Wylie JW,. Oblander SA, Madri J, Bianco P, Apte SS, Zaidi M, Doty SB,  Majeska RJ, Schaffler MB, Martignetti JA: Loss of MMP-2 disrupts skeletal and craniofacial development, and results in decreased bone mineralization, joint erosion and defects in osteoblast and osteoclast growth. Human Molecular Genetics, 16: 1113-1123, 2007

Heegaard AM , Corsi A, Danielsen CC, Nielsen KL, Riminucci M, Young MF, Bianco P. Biglycan deficiency causes spontaneous aortic dissection and rupture in mice. Circulation 115: 2687-2688, 2007  

Michienzi S, Cherman N, Holmbeck K, Funari A, Collins MT, Bianco P, Gehron Robey P, Riminucci M: GNAS transcripts in skeletal progenitors:  Evidence for random asymmetric allelic expression of Gsa. Human Molecular Genetics16:1921-1930, 2007

Sacchetti B, Funari A, Michienzi S, Di Cesare S, Piersanti S, Saggio I, Tagliafico E, Ferrari S, Gehron Robey P, Riminucci M, Bianco P: Self-renewing osteoprogenitors in bone marrow sinusoids can organize the hematopoietic microenvironment.  Cell 131: 324-336, 2007


Kuznetsov SA, Riminucci M, Ziran N, Tsutsui TW, Corsi A, Calvi L, Kronenberg HM, Schipani E, Gehron Robey P, Bianco P: The interplay of osteogenesis and hematopoiesis:  Expression of a constitutively active PTH/PTHrP receptor in osteogenic cells perturbs the establishment of hematopoiesis in bone and of skeletal stem cells in the bone marrow. Journal of Cell Biology 167:1113-1122, 2004

 

Cattelino A, Liebner S, Zanetti A, Gallini R, Balconi G, Corsi A,   Bianco P,   Wolburg H, Moore R,   Oreda B,   Kemler R and Dejana E: The conditional inactivation of beta-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility. Journal of Cell Biology 162: 1111-1122, 2003

Cossu G, Bianco P: Mesoangioblasts. Vascular progenitors for extravascular mesodermal tissues. Currrent Opinions in Genetics and Development 13:537-542, 2003

 Holmbeck K, Bianco P, Yamada S, Chrysovergis K Birkedal-Hansen H: MT1-MMP dependent, apoptotic remodeling of unmineralized cartilage: a critical process in skeletal growth. Journal of Cell Biology 163:661-671, 2003