In 1991 Giuseppe Zardo obtained his Pharmacy Degree with honors at the University of Rome "La Sapienza" and in 1997 got his PhD in Enzimology at the University of L'Aquila, School of Medicine. From 1997 to 2000 he was Short-term fellow at the European Molecular Biology Organization, Department of Biochemistry and Molecular Biology at the University of Glasgow and Post-doctoral Fellow at the Department of Sciences and Biomedical Technologies, Faculty of Medicine at the University of L’Aquila. From 2000 to 2003 he was Post-doctoral Fellow at the Department of Neurological Surgery, Brain Tumor Research Center at the University of California San Francisco. In 2004 he was Associate Specialist at the Department of Neurological Surgery, Brain Tumor Research Center at the same university. He is currently Researcher scientist at the Department of Cellular Biotechnologies and Hematology, Faculty of Medicine II at the University of Rome “Sapienza” and Professor of Clinical Chemistry at the School of Nursing and Biomedical Laboratory Technician, Faculty of Medicine II at the University of Rome “Sapienza”.

Selected publications

Zardo G, Cimino G, Nervi C. Epigenetic plasticity of chromatin in embryonic and hematopoietic stem/progenitor cells: therapeutic potential of cell reprogramming.Leukemia. 2008 22:1503-18.

Shing DC, Trubia M, Marchesi F, Radaelli E, Belloni E, Tapinassi C, Scanziani E, Mecucci C, Crescenzi B, Lahortiga I, Odero MD, Zardo G, Gruszka A, Minucci S, Di Fiore PP, Pelicci PG. Overexpression of sPRDM16 coupled with loss of p53 induces myeloid leukemias in mice. J Clin Invest. 2007 Dec;117(12):3696-707.

Fazi F, Zardo G, Gelmetti V, Travaglini L, Ciolfi A, Di Croce L, Rosa A, Bozzoni I, Grignani F, Lo-Coco F, Pelicci PG, Nervi C. Heterochromatic gene repression of the retinoic acid pathway in acute myeloid leukemia. Blood. 2007 14; 4432-40

Guccione E, Martinato F, Finocchiaro G, Luzi L, Tizzoni L, Dall' Olio V, Zardo G, Nervi C, Bernard L, Amati B. (2006) Myc-binding-site recognition in the human genome is determined by chromatin context. Nat Cell Biol. 8: 764-70.

Reynolds PA, Sigaroudinia M, Zardo G, Wilson MB, Benton GM, Miller CJ, Hong C, Fridlyand J, Costello JF, Tlsty TD. (2006) Tumor Suppressor p16INK4A Regulates Polycomb-mediated DNA Hypermethylation in Human Mammary EpithelialCells. J.Biol.Chem. 281: 24790-802.

Zardo G, Fazi F, Travaglini L, Nervi C. (2005) Dynamic and reversibility of  heterochromatic gene silencing in human disease. Cell Res. 15: 679-90

Ching TT, Maunakea AK, Jun P, Hong C, Zardo G, Pinkel D, Albertson DG, Fridlyand J, Mao JH, Shchors K, Weiss WA, Costello JF. (2005) Epigenome analyses using BAC microarrays identify evolutionary conservation of tissue-specific methylation of SHANK3. Nat Genet. 37: 645-51.

Zardo, G., Tiirikainen, M.I., Hong, C., Misra, A., Feuerstein, B.G., Volik, S., Collins, C.C., Lamborn K.R., Bollen, A., Pinkel, D., Albertson D.G. and Costello J.F. (2002): Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumours. Nature Genet. 32, 453-458.

Zardo, G., Reale, A., Passananti, C., Pradhan S., Buontempo, S., De Matteis, G., Adams, R.L.P. and Caiafa P. (2002): Inhibition of poly(ADP-ribosyl)ation induces DNA hypermethylation: a possible molecular mechanism. The FASEB Journal 16, 1319-1321.

Dangond, F., Henriksson, M., Zardo, G., Caiafa, P.,  Ekstrom, T.J. and Gray S.G. (2001): Differential expression of class I HDACs, roles of cell density and cell cycle. Intern. Journal of Oncology 19, 773-777.

Zardo, G., Marenzi, S., Perilli, M. and Caiafa P. (1999): Inhibition of poly(ADP-ribosyl)ation introduces an anomalous methylation pattern in transfected foreign DNA. The FASEB Journal 13, 1518-1522.

Zardo G. and Caiafa P., (1998): The unmethylated state of CpG islands in mouse fibroblasts depends on the poly(ADP-ribosyl)ation process. J. Biol. Chem. 273, 16517-16520.